甲壳低聚糖－硒对2型糖尿病大鼠血中糖、脂和胰岛素水平的影响
摘要
Purpose To investigate the effect of COS-Se on plasma glucose, lipid levels and insulin levels in rats with type 2 diabetes. Methods After the rat model of type 2 diabetes was established by a single injection of low dose streptozotocin after high fatty diet, the animals were divided into control group, COS-Se group, Se group and COS group. Other 10 rats were employed as normal control group. The levels of blood glucose, total cholesterol and insulin in the serum were determined. Results COS-Se group was compared with the Se group and COS group, and blood glucose was decreased remarkably (P＜0.05 or P＜0.01). COS-Se and COS could decrease serum total cholesterol in type 2 diabetes rats(P＜0.05 or P＜0.01), but there was no difference between the COS-Se group and the COS group (P＞0.05), and Se was non-effective in total cholesterol, and with the extension of time, COS-Se could improve high insulin level notably, compared with the Se group and COS group. Conclusion COS-Se could decrease serum glucose and total cholesterol levels, and improve insulin level.