1) 痰細胞化生之流行病學調查(2) 嚴重急性呼吸道症候群死亡之血液生化預測因子
摘要
(1) Epidemiology of sputum metaplasia In Taiwan, the annual mortality rate from lung cancer was approximately similar to the incidence rate of the disease in 1991~1993. Pulmonary diseases, including lung cancer, have been associated with the exposure to environmental tobacco smoking (ETS) and cooking oil fumes in addition to smoking. This study evaluated the detection of metaplsia in sputum and investigated corresponding prevalence and risk factors for metaplsia in sputum among general residents in Taipei areas. These associations were also evaluated for restaurant employees as separate sample. Study subjects being recruited in 2000~2001 received a pulmonary X-ray examination, completed a self-reported questionnaire for information on socio-demographic characteristics and life-style, and provided a specimen of the first sputum in the morning. This study included a total of 513 volunteer persons, recruited from Keelung City (158), Taipei City (130), and Taipei County (225). The results indicated that the subjects with metaplasia in sputum were younger than those without metaplasia in sputum, and had the best health status. The proportion of smokers among those with metaplasia in the sputum specimen was 35.7% or 1.4 times higher than that with no metaplasia in the sputum. After adjusting for age, gender, residential town and education, it was found that cooking and smoking history were significantly associated with developing metaplsia in sputum (p<0.05). Particularly, the odd ratio（OR） of metaplasia in sputum was 7.6 （95% confidence interval (CI)=1.5-39.2）for smokers with cooking, compared with smokers with no cooking or rarely cooked. In addition, the risk of metaplsia for smokers was 1.7~1.9 times higher than ex-smokers and non-smokers. No difference was found in the risk of metaplsia between ex-smokers and non-smokers. These results implied that smoking was likely related to the development of metaplsia in sputum. Using cigarette filter and emphysema were also ris