BMP-4和Ki-67在泌乳素腺瘤中的表达及临床意义
摘要
Objective: To investigate the expressions of bone morphogenetic protein-4 (BMP-4) and Ki-67 in prolactinomas and their relationships with invasiveness characteristics. Methods: The expressions of BMP-4mRNA, BMP-4 and Ki-67 protein in 35 cases of prolactinomas and 8 cases of normal pituitary tissues samples were detected by immunohistochemical and in situ hybridization technique, and the results were analysised by statistic method and their relationships were found. Results: The expressions of BMP-4mRNA, BMP-4 and Ki-67 was negative in normal pituitary tissues, and their expressions in 35 cases of prolactinomas was positively related with invasiveness grades (P＜0.01). The expressions of Ki-67 protein in grades 2~3 were significantly different from those in grades 0~1 in prolactinomas (P＜0.05). So the expressions of BMP-4mRNA, BMP-4 were more sensitive than the Ki-67 (P＜0.05), Conclusions: The BMP-4 was highly expressed in the prolactinomas and was positively related with the invasiveness grades.