MIC-1、PCNA在人脑星形细胞瘤中的表达及意义
摘要
Objective?To?investigate?the?expression?of?MIC-1?and?PCNA?in?human?brain?astrocytoma??and?its?correlation?with?Malignant?degree?and?pathologic?stage.?Methods?The?expression?of?MIC-1?and?PCNA?in?60?cases?of?the?human?brain?astrocytoma?and?5?cases?of?normal?brain?tissues?were?detected?by?immunohistochemistry.?Results?MIC-1?and?PCNA?in?normal?brain?tissue?do?not?express?but?the?expression?level?with?tumor?pathological?level?increased significantly higher in the human brain astrocytoma, its expression of Positive rate in normal brain tissue, low grade and high level astrocytoma is?compared?between?the?differences?were?statistically?significant(P<0.05)?and?expression?of?MIC-1?had?a?positive?correlation?with?the?expression?of?PCNA(P<0.05).?Conclusion?Expression?of?MIC-1?had?a?positive?correlation?with?the?expression?of?PCNA?in?human?brain?astrocytoma,?Prompt?the?excessive?expression?of?MIC-1?of?tumor?cell?proliferation?with?promoting?role.?it?may?become?the?new?candidate?tumor?markers,?For?judgment?of?malignant?degree?and?pathological?grade?provide?valuable?theory?and?basis.